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U.S. Health Researchers Test Zika Vaccine as Funds Run Low

The Zika virus can cause the birth defect microcephaly, marked by small head size that can lead to severe developmental problems in babies

A woman looks at a Centers for Disease Control (CDC) health advisory sign about the dangers of the Zika virus as she lines up for a security screening at Miami International Airport in Miami, Florida, May 23, 2016, photo: Reuters/Carlo Allegri
By Reuters Whatsapp Twitter Facebook Share
1 year ago

WASHINGTON — U.S. government researchers said on Wednesday they have begun their first clinical trial of a Zika vaccine while the Obama administration told lawmakers funds to fight the virus would run out in the coming weeks due to congressional inaction.

U.S. concerns over Zika, which is spreading rapidly in the Americas and has hit Brazil the hardest, have risen since Florida authorities last week reported the first signs of local transmission in the continental United States in a Miami neighborhood.

There is no approved vaccine or drug for Zika, a virus spreading rapidly in the Americas that can cause the birth defect microcephaly, marked by small head size that can lead to severe developmental problems in babies.

A number of companies and academic groups are racing to develop a Zika vaccine, which is not expected to be ready for widespread use for at least two to three years.

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health federal research agency, said its early-stage clinical trial will involve at least 80 healthy volunteers ages 18 to 35 at three study sites. It said the trial will evaluate the experimental DNA-based vaccine’s safety and ability to elicit an immune system response.

“A safe and effective vaccine to prevent Zika virus infection and the devastating birth defects it causes is a public health imperative,” NIAID Director Dr. Anthony Fauci said in a statement.

U.S. vaccine maker Inovio Pharmaceuticals in June won U.S. Food and Drug Administration approval to begin testing its Zika vaccine in humans. It began its clinical trial last month, aiming to enroll 40 healthy adult volunteers in Miami, Philadelphia and Quebec City.

President Barack Obama in February asked the Republican-led Congress for about $1.9 billion in emergency funds to combat Zika domestically and abroad, but lawmakers have not passed funding legislation.

A $1.1 billion compromise failed after House of Representatives Republicans attached language that would place restrictions on abortion and defund part of Obama’s signature 2010 healthcare law.

The administration has redirected $374 million from other health initiatives including combating the Ebola virus for stopgap Zika funding.

Obama’s health and human services secretary, Sylvia Burwell, told top congressional appropriators in a letter that the NIH will exhaust $47 million in repurposed funding by the end of the month.

She said without additional funding, the second phase of the NIH vaccine clinical trial would have to be delayed, which could prolong the development process.

“In addition, research and development of other vaccine candidates, diagnostics, therapeutics and (mosquito) vector control technologies may be constrained,” Burwell wrote.

She said the component within her department that provides funding to private-sector partners to develop medicines and vaccines will exhaust its $85 million in repurposed funding by the end of August.

She said the U.S. Centers for Disease Control and Prevention would virtually exhaust its $222 million in repurposed funds for its domestic Zika response by the end of September.



Public health officials have said small, localized outbreaks are likely in southern U.S. states already vulnerable to mosquito-borne disease. Florida said it would make Zika testing available to all pregnant women at county health departments statewide at no cost.

Texas health officials said they were on high alert for local Zika transmission and urged residents to follow precautions against mosquito bites.

“It’s the perfect mix – local transmission in Florida, travel to Brazil, and we’re at the height of mosquito season in Texas,” said John Hellerstedt, Texas Department of State Health Services commissioner, referring to the Olympic Games beginning this week in Rio.

Fauci said that while it will “take some time” before a vaccine against Zika is commercially available, the launch of the study marked an important step forward.

The study sites for the NIH vaccine trial were: NIH facilities in Bethesda, Maryland; the University of Maryland School of Medicine in Baltimore; and Emory University in Atlanta.

The Zika vaccine includes a piece of DNA that has been engineered to contain genes for proteins of the Zika virus. Such DNA vaccines do not contain infectious material so they cannot cause a person to become infected with Zika, the NIAID said.

New York Attorney General Eric Schneiderman said his office has sent cease-and-desist letters to seven companies accused of deceptively marketing ineffective Zika-protection products. Schneiderman also issued an alert warning consumers against the companies’ advertisements, which mainly promote ultrasonic and botanical oil-based mosquito repellants.

Will Dunham

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